Sodium-Potassium Ratios for Dogs with Canine Addison’s

The ability to diagnose Canine Addison’s by looking at serum sodium and potassium levels (electrolyte levels) is extremely limited. An article by Son-Il Pak, which was published in the Journal of Veterinary Science, highlights the difficulties with diagnosing any canine disease — including Addison’s disease in dogs — based on low Sodium-Potassium levels along. Typically, Addison’s dogs have elevated potassium (K) and low sodium (Na). While normal Na:K ratios are between 27.1 and 40.1, dogs with Canine Addison’s typically have ratios below 27.1. In some cases of primary Addison’s the levels may even dip below 20.1. However, these levels could indicate a variety of other diseases as well.

Outline of the Study

The study covered a period of two years at the Veterinary Medical Teaching Hospital, Seoul National University. During this time, 39 dogs with of low sodium-potassium serum levels (>27) were brought to to hospital. Out of those canines, 25.6% had a urinary or renal disease, and 15.4% had parasites. Other diagnoses included: deep pyoderma (skin infections), grade III patellar luxation (dislocated kneecap), bacterial pneumonia, diabetes, pancreatitis, diabetes, and pyometra (false pregnancy). The table below shows Na-K ratios and the primary diagnosis.

Na:K Ratio Primary Diagnosis
26.94 pancreatitis
26.32 patellar luxation
26.25 pancreatitis
26.21 bacterial pneumonia
26.07 patellar luxation
25.89 abdominal multiple bite wound
25.85 parasitism
25.74 parasitism
25.69 parasitism
25.42 portosystemic shunt
25.25 renal failure
25.00 heartworm infection
25.00 tarsal & metatarsal necrosis
24.83 steroid-induced hepatopathy
24.56 heart failure
24.13 hindlimb paralysis
24.10 preputal inflammation
23.97 urinary bladder & urethra mineralization
23.87 parasitism
23.78 bacterial pneumonia
23.75 pyroderma
23.33 renal failure
23.17 pyometra
23.13 diabetes
21.67 acute nephritis, renal failure
21.56 renal failure
21.19 renal failure
21.08 renal failure
19.72 renal failure
19.70 pyometra
17.18 renal failure
17.16 renal failure
16.85 renal failure
16.71 renal failure
15.75 hypoadrenocorticism(Canine Addison’s), renal failure
14.55 parasitism
14.30 pyoderma

Conclusion of the Study

While Na:K ratios can be useful in indicating